Nano-formulations: Recent Trends for Ocular Bioavailability Enhancement

Eye is a critical part of the body that readily available and with damage having direct effects on life an individual. Delivery ocular drugs always remain challenging for healthcare professionals scientists all over world due to challenges dynamic opthalamic environment provides. These involves different barriers like corneal epithelium, stroma, sclera other bio-membranes (static barriers), choroidal or conjunctival blood flow, lymphatic clearance, tear turnover (dynamic barriers) efflux pumps/enzymes(metabolic barriers).Ocular diseases include various affecting parts eye. The eye presents comprehensive perspectives difficulties in distribution medicaments, primarily exceptional ability inherent this mechanism enter main circulatory system also barrier limitations. Even if conventional non-invasive invasive treatments drops, injectable preparations implantable devices are but these either have bioavailability issues serious adverse effects. Additionally, new concept nanoscience nano-technology gives pathway treating disease. Different active molecules were engineered communicate nano-carriers pass interact closely unique specific tissues. This study highlights latest advances nano-formulations ophthalmic diagnosis provides discussions mainstream about role nearby future.
 Keywords: diseases, nano-technology, static barrier, nano-carriers, bioavailability.